The aetiology of deep venous thrombosis: a critical, historical and epistemological survey

What we now call ‘deep venous thrombosis’ (DVT) has been elucidated by a diversity of investigative approaches during the past four centuries. The authors of this book survey the history of the field and ask: why has one of these perspectives - the haematological/biochemical - come to dominate research into the causation of DVT during the past 50 years and to exclude alternatives? In answering this question, they show that the current consensus model is conceptually flawed. Building on the work of William Harvey, John Hunter, Rudolf Virchow, Ludwig Aschoff and a number of pathologists in the mid-20th century, they offer a revised account of the aetiology of this condition. In the process theyretrace and review the 160-year-old philosophical and methodological schism in biomedical research and, using DVT as an example, propose how this schism might be bridged to the benefit of both research and clinical practice. Challenges the current consensus in the field, which accounts for in vitro clotting and bleeding diatheses but fails to explain the aetiology of DVT. Proposes an aetiological hypothesis to unify perspectives and stimulate new approaches to productive research. Revives consideration of old (and new) approaches to the prophylaxis of venous thrombosis and thromboembolism. INDICE: Preface. Acknowledgments. Synopsis. Introduction to the study of deep venous thrombosis.-The coagulation cascade and the consensus model of DVT.Hypercoagulability. Historical roots. Coagulation and its disorders: a history of haematological research. Virchow and the pathophysiological tradition in the 19th century. The pathophysiological tradition after Virchow. Interrupted circulation: the ‘stasis’ hypothesis and the significance of venous valves. Underperfusion of valve pockets and the initiation of VVP. The role of endothelial hypoxia in DVT. The valve cusp hypoxia hypothesis. Molecular changes in thehypoxic endothelium. Cadaver blood or agonal thrombi?- Appendix: science, medicine and philosophy.

• ISBN: 978-1-4020-6649-8
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 265
• Fecha Publicación: 01/01/2008
• Nº Volúmenes: 1
• Idioma: Inglés