Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease fills a significant void, providing a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will find this book to be a go-to resource for both the biology and medical applications that focus on sirtuins. Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entitiesSummarizes the multidiscipline views and publications on this diverse topic, covering cell development, cardiovascular and pulmonary systems, neurodegenerative disorders, cancer and metabolism INDICE: Section I. Sirtuins in Cellular Development, Growth, Differentiation, and Senescence 1. Sirtuins, Cellular Trafficking, and Post-Translation Modification 2. Sirtuins and Modulation of Programmed Cell Death with Apoptosis and Autophagy 3. Sirtuins and Stem Cell Maintenance, Proliferation, and Differentiation 4. Sirtuins, Implantation, Fertility, and Reproductive Function 5. Sirtuins, Mitochondrial Dysfunction, and Genetic Disorders Section II. Sirtuins in the Cardiovascular and Pulmonary Systems 6. Sirtuins and Cardiovascular Injury 7. Sirtuins and Cardiac Hypertrophy 8. Sirtuins, Atherosclerosis, and Vascular Injury 9. Sirtuins and Smooth Muscle Proliferation 10. Sirtuins, Fibrotic Disease, and Cardiopulmonary Dysfunction Section III. Sirtuins in Acute and Chronic Neurodegenerative Disorders 11. Sirtuin Modulation of Mood Disorders and Drugs of Addiction 12. Sirtuins in Chronic Neurodegeneration and Neuronal Aging 13. Sirtuins in Cognition, Dementia, and Alzheimer's Disease 14. Sirtuins and Acute Neurodegeneration, Trauma, and Stroke 15. Sirtuins and Epilepsy, Parkinson's Disease, and Huntington's Disease Section IV. Sirtuins in Cancer and Immune Dysfunction 16. Sirtuins, T-cell trafficking, and immune responses 17. Sirtuins and Molecular Regulation of Cellular Anti-tumor Immunity 18. Sirtuins and Solid Tumors in the Gastrointestinal, Genitourinary, and Renal Systems 19. Sirtuin signaling in Leukemia and Blood Borne Malignancies 20. Sirtuins and Endocrine Tumors Section V. Sirtuins and the Control of Metabolism 21. Sirtuins and Cellular Energy 22. Sirtuins, Nutrition, and Dietary Control 23. Sirtuins, Redox imbalance, Oxidative Stress, and Altered Metabolic Pathways 24. Sirtuins, B-cell Function, and Insulin Tolerance 25. Sirtuins and Lifespan Extension

• ISBN: 978-0-12-814118-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 512
• Fecha Publicación: 01/06/2019
• Nº Volúmenes: 1
• Idioma: Inglés