Forkhead transcription factors: vital elements in biology and medicine

Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse andcomplex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potentialof forkhead transcription factors for new therapeutic avenues in multiple disciplines. INDICE: Section I. Insights into immunity, infection and cancer: Foxo1, t-cell trafficking and immune responses. Foxp3 and its role in the immune system. Molecular regulation of cellular immunity by Foxp3. The biology of Foxp3: a key player in immune suppression during infections, autoimmune diseases and cancer.- Section II. elucidating the components responsible for vascular development and disease in the cardiovascular system: the cooperative roles of Foxc1 and Foxc2 in cardiovascular development. Foxo proteins and cardiac pathology. The forkhead transcription factors play important roles in vascular pathology and immunology. Regulatory t-cells, Foxp3 and atherosclerosis.- Section III. dissecting the pathways of neuronal integration and plasticity in the nervous system: Foxp genes, neural development, speech and language disorders. pathophysiological relevance of forkhead transcription factors in brain ischemia. New insights for Foxo and cell-fate decision in HIV infection and HIV associated neurocognitive disorder.- Section IV. translating vital cellular mechanisms into successful clinical care: Foxp3+ regulatory t-cells in chronic kidney disease: molecular pathways and clinical implications. Transcriptional role of Foxo1in drug resistance through antioxidant defense systems. Foxp3 expressing regulatory t-cells in allergic disease. Human clinical phenotype associated with foxn1 mutations. Foxl2: at the crossroads of female sex determination and ovarian function. Foxo transcription factors: from cell fate decisions to regulation of human female reproduction. The 'o' class: crafting clinical care with Foxo transcription factors.

• ISBN: 978-1-4419-1598-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 292
• Fecha Publicación: 01/01/2010
• Nº Volúmenes: 1
• Idioma: Inglés