Transition Metal-Catalyzed Couplings in Process Chemistry

This one–stop reference source is the first on this new and exciting technology to focus on case studies of large–scale industrial applications, presenting the information and facts that are otherwise hard to find in the current literature. Authors from Pfizer, Merck, DSM, Novartis, Amgen, and Astra Zeneca, among others, use case studies to showcase project evolution from inception to early and late development, including commercial routes where applicable.  Each case study details at least one transition metal–catalyzed cross–coupling step, with special emphasis on lessons learned from their implementation. The important issue of metal removal from the reaction mixtures to meet specifications and the different technologies available to accomplish this goal are also addressed. Finally, a small section covers novel technologies for cross–coupling with high future potential for applications on a large scale, such as metal removal on large scale, microwave and flow chemistry, as well as green chemistry. Of great interest to chemists working in the pharmaceutical, agrochemical and fine chemical industries, but also for every synthetic chemist working in academia. INDICE: Case study with Heck/Suzuki chemistry Case study with Buchwald–Hartwig amination Case study with Suzuki coupling Case study with Ullmann–type chemistry use of nanocatalysts in cross–coupling reactions Case study on Negishi and Suzuki couplings Transition metal–catalyzed cross–coupling reactions under microwave and flow chemistry conditions Case study on Sonogashira coupling Case study on Tsuji–Trost allylation Case studies on cyanation, Buchwald–Hartwig amination Case study on Buchwald–Hartwig amination Case study on Kumada coupling

• ISBN: 978-3-527-33279-3
• Editorial: Wiley VCH
• Encuadernacion: Cartoné
• Páginas: 401
• Fecha Publicación: 04/09/2013
• Nº Volúmenes: 1
• Idioma: Inglés