Heart disease is the leading cause of death in the UK and the United States. For those people who survive heart disease, few victims recover completely. Cell therapies, tissue engineering and biomaterials technologies have advanced and now offer the potential to reverse the damage caused by heart disease. Volume 1 of this important book provides readers with comprehensive information on biomaterials and tissue engineering as strategies for the repair and regeneration of the heart. The book begins with an introduction to the field, and following chapters look at biomaterials for regeneration and repair of the heart. Further chapters discuss tissue engineering strategies for the regeneration and repair of the heart whilst the final chapters review vascular modelling and regeneration.Volume 2 reviews the use of biomaterials, alone or combined with cell therapy, to provide tissue engineered constructs to repair the injured heart and prevent or reverse heart failure. INDICE: Volume 1 Part 1 The pathogenesis of congestive heart failure: Cardiac matrix remodeling and heart failure; Cardiac biomechanics and heart dysfunction; Modifying matrix remodeling to prevent heart failure. Part 2 Cell therapy for cardiac regeneration and repair: Optimal cells for cardiac repair and regeneration; Cell delivery routes for cardiac stem cell therapy; Cell therapy to regenerate the ischemic heart; Cell therapy for cardiac repair - bench to bedside and back; Recent advances in cardiac stem cell therapy to restore left ventricular function; Monitoring myocardial functional regeneration following cardiac stem cell application; Feasibility of allogeneic stem cells for heart regeneration; Bone marrow cells and their role in cardiac repair after myocardial infarction. Part 3 Stem cells for cardiac regeneration and repair: Cardiac cell therapy to restore contracting elements; Human embryonic stem cells (hESCs) for heart regeneration; Human pluripotent stem cells (hPSCs) for heart regeneration; Cardiac cell therapy: Current status and future trends. Part 4 Gene therapy for cardiac regeneration and repair: Stem cell and gene therapy for cardiac regeneration; Ultrasound-targeted cardiovascular gene therapy. Volume 2 Part 1 Biomaterials for cardiac regeneration and repair: Nanotechnology and nanomaterials for cardiac repair; Hydrogels for cardiac repair; Injectable biomaterials for cardiac regeneration and repair; Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration; Endothelial progenitor cell (EPC)-seeded intravascular stents. Part 2 Tissue engineering for cardiac regeneration and repair: Biomaterials and cells for cardiac tissue engineering; Decellularized biologic scaffolds for cardiac repair and regeneration; Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix; Cell sheet engineering for cardiac repair and regeneration; Maturation of functional cardiac tissue patches; Vascularizing engineered tissues for in vivo and in vitro applications; Clinical considerations for cardiac tissue engineering. Part 3 Vascular remodelling for regeneration and repair: Aortic extra cellular matrix (ECM) remodelling; Cell-biomaterial interactions for blood vessel formation; Stem cells in tissue-engineered blood vessels for cardiac repair; Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESAT).
- ISBN: 978-1-78242-299-0
- Editorial: Woodhead Publishing
- Encuadernacion: Cartoné
- Páginas: 992
- Fecha Publicación: 31/01/2014
- Nº Volúmenes: 1
- Idioma: Inglés