Cardiac Regeneration And Repair: Pathology and Therapies

Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular functionHighlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac functionExplores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration INDICE: Part 1 The pathogenesis of congestive heart failure: Cardiac matrix remodeling and heart failure; Cardiac biomechanics and heart dysfunction; Modifying matrix remodeling to prevent heart failure. Part 2 Cell therapy for cardiac regeneration and repair: Optimal cells for cardiac repair and regeneration; Cell delivery routes for cardiac stem cell therapy; Cell therapy to regenerate the ischemic heart; Cell therapy for cardiac repair - bench to bedside and back; Recent advances in cardiac stem cell therapy to restore left ventricular function; Monitoring myocardial functional regeneration following cardiac stem cell application; Feasibility of allogeneic stem cells for heart regeneration; Bone marrow cells and their role in cardiac repair after myocardial infarction. Part 3 Stem cells for cardiac regeneration and repair: Cardiac cell therapy to restore contracting elements; Human embryonic stem cells (hESCs) for heart regeneration; Human pluripotent stem cells (hPSCs) for heart regeneration; Cardiac cell therapy: Current status and future trends. Part 4 Gene therapy for cardiac regeneration and repair: Stem cell and gene therapy for cardiac regeneration; Ultrasound-targeted cardiovascular gene therapy.

• ISBN: 978-0-85709-658-6
• Editorial: Woodhead Publishing
• Encuadernacion: Cartoné
• Páginas: 464
• Fecha Publicación: 22/01/2014
• Nº Volúmenes: 1
• Idioma: Inglés