Phenotypic Switching: Implications in Biology and Medicine

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studiesFeatures a diverse range of chapter contributions from international leaders in the field INDICE: 1. Quantifying Waddington landscapes and paths of cell fate decisions 2. The physics of cell fate 3. Stochastic phenotypic switching in endothelial cell heterogeneity 4. For an augmented epistemology of chance in the study of cell differentiation and development 5. Manoeuvring protein functions and functional levels by structural excursions 6. Cell-state organization by exploratory sloppy dynamics 7. Random walk across the epigenetic landscape 8. Metabolic Constraints and Phenotypic Switching: Evidence From Theory and Experiment 9. Dissecting environmentally induced and stochastic developmental phenotype variation 10. Cell differentiation in animals: metazoan-specific amplification hubs of inherent cell functions 11. Regulation of developmental plasticity from the perspective of evolutionary developmental biology 12. Phenotypic and functional variation in bird song dialects. 13. Domestication as a Process Generating Phenotypic Diversity 14. Evolution by developmental scaffolding: Acquiring new phenotypes through sympoiesis 15. Bitter-Sweet Dimensions to Ovarian Cancer Progression and Metastasis 16. Phenotypic plasticity and the origins of novelty 17. Epithelial-Mesenchymal Transition in Cancer 18. Phenotypic switching and prostate diseases: A model proposing a causal link between benign prostatic hyperplasia and prostate cancer 19. Phenotypic switching and lineage switching in prostate cancer 20. Implications of non-genetic heterogeneity in cancer drug resistance and malignant progression 21. Phenotypic plasticity: the emergence of cancer stem cells and collective cell migration 22. Bistability in Virus-Host Interaction Networks Underlies the Success of Hepatitis C Treatments 23. Adaptive phenotypic switching in breast cancer in response to matrix deprivation 24. Phenotypic instability induced by tissue disruption at the origin of cancer 25. Phenotypic plasticity in fungi mediated by switches in protein conformation 26. Incorporating evolutionary dynamics of cancer to design adaptive treatment strategies

• ISBN: 978-0-12-817996-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 1112
• Fecha Publicación: 01/06/2020
• Nº Volúmenes: 1
• Idioma: Inglés