Insulin-like growth factors and cancer: from basic biology to therapeutics

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer. Comprehensive look at the history of targeted therapies in cancer. Edited by a recognized expert in IGF Systems and cancer. Discusses the successes and failures of targeted therapies and cancer. INDICE: Preface. Epidemiology of IGF-1 and Cancer. Aging and Cancer: The IGF-I Connection. Obesity, Type 2 Diabetes and Cancer. IGF System and Breast Cancer. The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression. Mouse Models of IGF-1 Deficiency. Insulin-like GrowthFactor Signaling in Pediatric Sarcomas. Cancer Genes, Tumor Suppressors, and Regulation of IGF-1R Expression in Cancer. Mouse Models of IGF-1R and Cancer. Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy. Targeting Insulin-like Growth Factor (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer. Calories and Cancer: The Role of Insulin-like Growth Factor. Cancer Cell Metabolism. Overlaps between the Insulin and IGF-1R and Cancer. Index

• ISBN: 978-1-4614-0597-9
• Editorial: Springer US
• Encuadernacion: Cartoné
• Páginas: 191
• Fecha Publicación: 28/10/2011
• Nº Volúmenes: 1
• Idioma: Inglés