From local invasion to metastatic cancer: involvement of distant sites through the lymphovascular system

In human solid tumors, nodal status is the most important prognostic indicator for patients’ outcome. Recent developments in the sentinel lymph node concept have resulted in a procedure to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System,a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines theprocess of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. Summarizes the findings of the Second International Symposium onCancer Metastasis: Basis for Rational Therapy Provides and exhaustive review of major developments in the biologic and clinical understanding of cancer metastasis. Discusses and summarizes the therapeutic results of the latest new approaches in cancer treatment INDICE: From the contents Introduction.- Dynamic Reciprocity Between TumorCells and the Microenvironment.- Inflammation as a Regulator of Epithelial Cancer Development.- Targeting Molecular Signals in the Tumor Cell Microenvironment.- Convergence of Embryonic and Tumorigenic Pathways: Role in Tumor Progression.- Heme-Lymph Vasculo/Angiogenesis, Angiotumorigenesis, and Tumor Angiogenesis: A Lymphatic System Perspective.- Model Systems to Study Lymphangiogenesis and Angiogenesis: Lessons for Tumor Biology.- Vascular Permeability Factor, Lymphangiogenesis/Angiogenesis, and Cancer Biology.- Molecular Events and Clinical Correlations in Tumor and Other Lymphangiogenesis.- Tumor Lymphangiogenesis: What We Know and Don't Know.- Molecular Imaging of Cancer - Receptors, Angiogenesis and Gene Expression.- MRI and Ultrasound Imaging of Lymph Node.- Molecular Imaging of the Sentinel Lymph Node.- Lymphatic Dysfunction and Scintigraphy in Cancer Patients.- Molecular Imaging of Neuroendocrine Cancer by fusionSPECT/CT.

• ISBN: 978-1-60327-086-1
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 860
• Fecha Publicación: 01/03/2009
• Nº Volúmenes: 1
• Idioma: Inglés