Sex, Gender, and Epigenetics: From Molecule to Bedside explores the complex interplay of sex and gender-based influences on gene expression via epigenetic mechanisms. The book provides an overview of the field and evidence gathered to-date that is followed by a discussion of epigenetic pathways by which biological sex and the impact of the environment collaborate to regulate genetic function. The book also analyzes the impact of ancestors' environmental experience on subsequent generations and describes the nature of sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics. Examines the impact of biological sex and gender on gene expression through epigenetic mechanisms, and its relationship to human biology and disease Presents the current state of our understanding of how environmental experience is translated to future generations in a sex specific manner Features chapter contributions from international leaders in the field INDICE: 1. Introduction2. Fetal programming3. Pharmacology4. Gender- and Sex Conscious Medicine with Epigenetics in Mind5. Cancer and Epigenetics6. Personal Medicine7. Male Reproduction Epigenetics8. ART Epigenetics9. Epigenetics and the Microbiome10. Stress11. Sex differences in Gene Regulation in the Brain12. Epigenetics and the Development of Sex Differences in the Brain13. Integrative Transcriptomes Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder14. Transgenerational Epigenetic Inheritance Of Cancer Susceptibility Through The Paternal Germ Line15. Epigenetic Adaptation Of Ovarian Cancer16. Cancer epigenetics: Assembly And Function Of Nuclear Domains17. The epigenetic consequences of infertility and assisted reproduction technology in humans18. Epigenetic Aspects of Human Oocyte Aging19. Limited Epigenetic Variation Following Conception Via ART20. Epigenetic Competence Of Mammalian Gametes And Its Effect On Embryogenesis21. Heritable Memories22. Epigenetic Inheritance Of Acquired Traits Through Sperm RNA's And RNA Modifications23. Mother-Child Transmission Of Epigenetic Information By Tunable Polymorphic Imprinting24. Stable Phenotype Inheritance From Parents Of Genetic Sequence Per Se25. Individual Differences; Gene-Environment Interplay and Epigenetics26. Conclusion and Future Research
- ISBN: 978-0-12-823937-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 408
- Fecha Publicación: 01/06/2023
- Nº Volúmenes: 1
- Idioma: Inglés