Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allowsoptimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biologyand biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis,genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli.Complete and state-of-the-art coverage of systems biology and biotechnology of E. coli Coverage of all levels of omics and genome-scale computational studies in E. coli Comprehensive coverage of engineering E. coli, and biotechnological applications Contributions from world-leading experts in the fields INDICE: From the contents 1 Biological Features and Biotechnological Applications of Escherichia coli B: "Is B for better?!" 2 E. coli Genome Engineering and Minimization for the Construction of a Bioengine. 3 Multi-omics Data-driven Systems Biology of E. coli. 4 A Medium-Throughput Structural Proteomics Approach Applied to the Genome of E. coli. 5 Resources for Escherichia coli Systems Biology. 6 The Multiple Scientific Disciplines Served by EcoCyc. 7 Analysis of E. coli Network. 8 Sensory Transduction Network of E. coli. 9 Genome-Scale Reconstruction, Modeling, and Simulation of E. coli’s Metabolic Network. 10 Kinetic Modeling of E.coli Enzymes: Integration of in vitro Experimental Data.11 Dynamic Modeling of the Central Metabolism of E. coli – Linking Metaboliteand Regulatory Networks. 12 Genome-scale Models and the Genetic Basis for E. coli Adaptation. 13 Organisation of Complex Escherichia coli Promoters. 14 Plasmid Regulation and Systems-Level Effects on Escherichia coli Metabolism.
- ISBN: 978-1-4020-9393-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 482
- Fecha Publicación: 01/03/2009
- Nº Volúmenes: 1
- Idioma: Inglés