Laron syndrome : from man to mouse: lessons from clinical and experimental experience

Laron Syndrome covers the relationship between GH and IGFI and their phenotypic effects. These effects can generally be separated into growth and metabolicdefects. In this unique book, the authors illustrate and demonstrate the interesting results of the short and long-term effects of the mutation and give valuable treatment advice. This book is a helpful resource for pediatricians, endocrinologists and internists as well as researcher in the field of genetics and biology. First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him) Describes the comprehensive pathophysiology of IGF-I deficiency andgives valuable advice for the IGF-I treatment Compares IGF-I and GH deficiency and illustrates the effects of the treatment, e.g. metabolic effects, adipose tissue alterations and the effects on aging INDICE: "From the Content: Part I - Laron Syndrome in Man.- Clinical Aspects.- History of the Israeli Cohort of Laron Syndrome Patients.- Early Investigations.- Clinical Evidence of Growth Hormone Resistance in Patients with LaronSyndrome.- Diagnosis of Laron Syndrome.- Genetic Aspects.- Clinical Evaluation.- Perinatal Evaluation.- Perinatal Development ;Laron Syndrome.- Linear Growth Pattern of Untreated Laron Syndrome Patients.- Head Shape, Size and Growth of Untreated Patients with Laron Syndrome.- Sexual Development in Patients with Laron Syndrome."

• ISBN: 978-3-642-11182-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 428
• Fecha Publicación: 01/10/2010
• Nº Volúmenes: 1
• Idioma: Inglés