Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as the challenge of integrating epigenetics into pharmacogenomics research, pharmacoeconomics, cost-effectiveness and reimbursement. Ethnicity and ethno-bridging in translating and implementing scientific findings worldwide is also discussed. With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomicsHighlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testingIncludes discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion INDICE: 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications 2. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics 3. Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 4. Study Designs in Pharmacogenomics Research 5. Incorporating Pharmacogenomics in Drug Development: Industry and Regulatory Perspectives 6. Translating Pharmacogenomic Research to Therapeutic Potentials - Ethical Considerations and Challenges in Pharmacogenomics 7. Pharmacogenomics in Cancer Therapeutics 8. Pharmacogenomics in Cardiovascular Diseases - Lessons Learned from Warfarin 9. Pharmacogenomics in Psychiatry Disorders - Lessons Learned from Antidepressants and Antipsychotics 10. Role of Pharmacogenomics in HIV Infection - Lessons Learned from Efavirenz 11. Role of Pharmacogenomics in Diabetes - Lessons Learned from Metformin? 12. A Look to the Future: Pharmacogenomics, Pharmacoepigenomics, and System Biology - Data Technologies of Today and Tomorrow 13. The Importance of Race and Ethnicity in Pharmacogenomics 14. Reactive, Point-of-Care, Pre-emptive and Direct-to-Consumer Pharmacogenomic Testing 15. Cost-effectiveness and Pharmacogenomic Testing Reimbursement 16. Pharmacogenomics Education and Clinical Practice Guidelines

• ISBN: 978-0-12-812626-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 544
• Fecha Publicación: 01/10/2018
• Nº Volúmenes: 1
• Idioma: Inglés