Medicinal Chemistry Approaches to Personalized Medicine

Edited by two famous medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of personalized dugs are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. INDICE: Introduction ONCOLOGY Diagnostics Crizotinib Zelboraf Vismodegib G–quadruplexes as therapeutic targets in cancer Identifying actionable targets in cancer patients DNA damage repair pathways and synthetic lethality NEUROSCIENCES Amyloid chemical probes and theranostics: steps toward personalized medicine in neurodegenerative diseases LRRK–2 Genes to drugs for CNS disorders The Alzheimer?s Prevention Initiation study INFLAMMATION Kinases in asthma Epigenetics FUTURE PERSPECTIVES Future perspectives in personalized medicine Developing targeted PET probes in the era of personalized medicine

• ISBN: 978-3-527-33394-3
• Editorial: Wiley VCH
• Encuadernacion: Cartoné
• Páginas: 408
• Fecha Publicación: 18/12/2013
• Nº Volúmenes: 1
• Idioma: Inglés