TDP-43 and Neurodegeneration: From Bench to Bedside

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43's structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathologyIdentifies TDP-43 role in ALS, FTP, and other neurodegenerative diseasesPresents a systems and precision biology perspective of TDP-43Discusses therapeutics of TDP-43 proteinopathiesTranslates bench research to application bedside INDICE: 1. TDP-43: Past, Present and Future2. Structural studies of TDP-433. TDP-43 mutations and Amyotrophic Lateral Sclerosis4. Post translational modifications of TDP-435. TDP-43 and Autophagy6. TDP-43 and Alzheimer Disease7. TDP-43 and Stress granules8. Repeat domains in TDP-438. Systems Biology of TDP-439. Animal models of TDP-43 in ALS10. Therapeutic modulations of TDP-43

• ISBN: 978-0-12-820066-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/06/2021
• Nº Volúmenes: 1
• Idioma: Inglés