Dendrimers are engineered nano-sized macromolecule with a high degree of molecular uniformity, narrow size distribution, tunable size, multivalency and high surface functionality. These favourable characteristics make dendrimers effective drug delivery carriers. As a result, dendrimers have demonstrated wide applicability in nanopharmaceuticals Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in solubilisation of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. Dendrimers have been successfully used as a solubility enhancer and drug delivery carrier. Dendrimer-based formulations have also been used for transfection or gene delivery. Diagnostic applications of dendrimers include MRI contrast agent and imaging of diseased areas. In addition, dendrimers such as PPI and PAMAM are reported to possess anti-inflammatory, antimicrobial and antiviral activities. In past five years, photosensitizers such as rose Bengal and protoporphyrin IX have also been delivered using PAMAM and PPI dendrimers for the treatment of cancer. These important and emerging uses are discussed here in detail. This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery. Explores the role of dendrimers in the design of dendritic nanoplateforms for targeted drug and gene delivery systemsDiscusses the potential of dendrimers in preformulation and formulation developmentAddresses the clinical and regulatory challenges in the development of dendrimer-based formulations INDICE: 1. Dendrimers: Introduction, types and properties2. Dendrimers as solubility enhancer or excipient3. Dendrimers as therapeutic agent/drug4. Biocompatibility and toxicity of dendrimers5. Dendrimers as drug delivery carrier6. Dendrimers for the delivery of biological drugs7. Pharmacokinetic considerations in design of dendrimer-based nanomedicines8. Design of dendrimer-based prodrugs9. Stimuli-responsive dendrimers in drug delivery10. Dendrimer-based targeted drug delivery11. Dendrimers in photodynamic therapy12. Diagnostic applications of dendrimer based nanovectors13. Overview of current clinical status of dendrimer-based formulations
- ISBN: 978-0-12-814527-2
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 500
- Fecha Publicación: 01/11/2019
- Nº Volúmenes: 1
- Idioma: Inglés