Phagocytosis of dying cells: from molecular mechanisms to human diseases

This comprehensive volume integrates the most innovative and current findingsfrom several related disciplines of scientific research, including pathology,immunology, genetics, and cellular and molecular biology. It is divided into two sections: “Molecular mechanisms of phagocytosis of dying cells” and “Impairment of phagocytosis of dying cells and its role in the development of diseases”. No other recent books devoted to this subject are available. All of the contributors are experts working at the forefront of scientific discovery, and the reviews they present systematically examine the most exciting and innovative aspects of their particular areas of expertise. Both researchers and physicians will find this volume of major benefit because it covers the immunological and molecular biological aspects of phagocytosis of dying cells as well as its clinical relevance. The first book on this subject Devoted to describing the molecular mechanisms of phagocytosis of dying cells and examining the impactof defective clearance of dying cells on the immune function and development of human diseases Will be of great interest and value for students in medical,biomedical and biotechnological faculties and for researchers in biotechnological companies INDICE: From the contents Part I. Molecular mechanisms of phagocytosis of dying cells: 1. Molecular pathways of different types of cell death: many roads to death. 2. Apoptotic. necrotic and autophagic cell death types in pathophysiological conditions: morphological and histological aspects. 3. Role of attraction and danger signals in the uptake of apoptotic and necrotic cells and its immunological outcome. 4. Molecules involved in recognition and clearance ofapoptotic/necrotic cells and cell debris. 5. Evolutionarily conserved pathways regulating engulfment of apoptotic cells. 6. Innate apoptotic immunity: a potent immunosuppressive response repertoire elicited by specific apoptotic cellrecognition. 7. Comparative characterization of non-professional and professional phagocyte responses to apoptotic cells. 8. Methods used to study apoptotic cell clearance.

• ISBN: 978-1-4020-9292-3
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 454
• Fecha Publicación: 01/03/2009
• Nº Volúmenes: 1
• Idioma: Inglés