The biological sciences are now in the midst of a true life sciences revolution akin to what physics experienced just after the turn of the last century. We are now in a phase of unparalleled growth that is reflected by the amount ofdata generated from each experiment. At the time of this writing, the rate ofdata acquisition was approaching 2 terabytes over the course of 5 days with first pass analysis proceeding over the following 2-3 week period. This fundamental shift has provided unprecedented opportunities that for the first time afford us the ability, i.e., means, breadth, and depth of data, to truly addresshuman biology at the systems level. This wealth of information from seeminglydisparate datasets and its integration is being realized through bioinformatics. It is with this philosophy that the text Bioinformatics for Systems Biology was born. This revolution has spawned true personalized medicine that encompasses diagnostics and treatment through to cure. INDICE: From the contents Life of a Cell and its Analysis: Structure and Function of the Nucleus and Cell Organelles.- Transcription and the Control of Gene Expression.- RNA Processing and Translation.- DNA Replication, Recombination, and Repair.- Cell signalling.- Epigenetics of Spermiogenesis: combining in silico and proteomic approaches in the mouse model.- Genomic Tools for Analyzing Transcriptional Regulatory Networks.- Statistical Tools and Their Application: Probability and Hypothesis Testing.- Stochastic Models for Biological Patterns.- Population Genetics.- Statistical tools for gene expression analysis and system biology and related web resources.- Transcriptome Analysis: What goes in is what comes out: How to design and implement a successful microarray experiment.- Tools and Approaches for an End-to-End Expression Array Analysis.-Analysis of alternative splicing with microarrays.
- ISBN: 978-1-934115-02-2
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 750
- Fecha Publicación: 01/09/2008
- Nº Volúmenes: 1
- Idioma: Inglés