Immune Infertility: the impact of immune reactions on human infertility

This comprehensive overview of immune reactions inducing fertility disorders in both sexes first describes the nature and the function of sperm antigens which are capable to induce immune infertility as well as the methods to analyseand characterize these antigens. Secondly, the nature, the origin and induction of antisperm antibodies (ASA) in both sexes and the role of reproductive organs and their interaction with the immune system will be discussed. A large section of the book, which is most important for clinicians working in reproductive medicine, deals with the clinical impact of the immune reaction in reproductive medicine, including the methods of determination and the treatment in immune infertility. Closely related to immune infertility is the development ofimmune contraceptives which is also discussed. INDICE: Sperm Antigens: Proteomics of Spermatozoa.- Methods of Analysis.- Sperm Functions Influenced by Immune Reactions.- Antisperm Antibodies (ASA): The Immune Privilege of the Testis.- Immune Chemistry of ASA.- Sperm-Specific TCells.- Site and Risk Factors of ASA Production.- Biologic Substrates Containing ASA.- ASA in the Female.- The Clinical Impact of Sperm Antibodies: Autoimmune Infertility.- Tests for Sperm Antibodies.- Impact on Fertility Outcome.- Sperm Antibodies and Assisted Reproduction.- Treatment of Immune Infertility.- Immune Contraception: Antigens Suitable for Induction of Immune Reaction.- Immune Contraception in Wildlife Animals. Experiences with Human Trials

• ISBN: 978-3-642-01378-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 242
• Fecha Publicación: 10/09/2009
• Nº Volúmenes: 1
• Idioma: Inglés