Authored by the world?s leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co–substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome–based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference. INDICE: PART 1: Protein Kinases Cell Signaling. ?Genuine? Casein Kinase (Fam20C): The Mother of the Phospho–Secretome. Chemical Biology of Protein Kinas. Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis. The Kinomics of Malaria. PART 2: ATP Co–Substrate Design. ATP Analogs in Kinase Research. Electrochemical Detection of Protein Kinase Catalyzed Phosphorylations. PART 3: New Methodologies for Kinomics. Phos–tag Technology for Kinomics. Development of Species– and Process–Specific Peptide Kinome Arrays with Priority Application to Investigations of Infectious Disease. New Approaches to Understanding Bacterial Histidine Kinase Activity and Inhibition. Methods for Large–Scale Identification of Protein Kinase–Substrate Networks. PART 4: Kinase Inhibition. Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease. Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands. .
- ISBN: 978-3-527-33765-1
- Editorial: Wiley VCH
- Encuadernacion: Cartoné
- Páginas: 368
- Fecha Publicación: 23/09/2015
- Nº Volúmenes: 1
- Idioma: Inglés