Tumor infiltrating B lymphocytes: a novel approach for cancer diagnostics and therapeutics

Over the past few decades, a great many laboratories have focused on the identification of novel tumor antigens that would be potential targets for tumor diagnostics and therapeutics. In spite of important findings in the field, the urgent need for the development of early tumor diagnosis and effective anti-tumor therapies remains. This work intends to provide a relatively broad audience with a novel approach for the development of cancer diagnostics and targetedtherapeutics, based on recently proved hypotheses. It will provide comprehensive coverage of the most important aspects of a selected domain of tumor immunology, namely the characteristics and potential capacity of the tumor infiltrating B lymphocytes. Introduces the readers to the highly interesting matter oftherapeutic drug discovery, based on a great variety of possibilities in antibody engineering and biotechnology. Researchers, clinicians, medical students (and eventually some patients with interest) will be guided through this exiting methodological pathway INDICE: Tumor Infiltrating T Lymphocytes.- Tumor Infiltrating B Lymphocytes.- B Lymphocytesin Different Solid Tumors: Melanomas, Breast Carcinomas, Ovarian Carcinomas, Neuroblastoma.- Results of Immunoglobulin Repertoire Analysis Fetal and Adult Normal B Cells Compared to B Cells from Tumor Tissues.- Potential Capacity of Natural Human Antibodies.- Potential Capacity of Autoantibodies.- Potential Capacity, Benefits and Drawbacks of Different Antibody Fragments.- Methodological Arsenal of Antibody Engineering and Biotechnology.- The Secret of Tumor Infiltrating Lymphocytes.- The ‘Sleeping Beauty’ Might be Awaked.-Achievements and Future Prospects for Novel Tumor Diagnostics and Therapeutics.- The Benefits of Targeted Therapeutics to Defeat Cancer.

• ISBN: 978-0-387-69881-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 160
• Fecha Publicación: 01/04/2008
• Nº Volúmenes: 1
• Idioma: Inglés