Drug product development for the back of the eye

This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. . Specific topics covered in this book include:. Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drugproduct development Emerging and existing drugs and drug targets . Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back ofthe eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets . Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of deliveryPhysical methods including iontophoresis for drug delivery Rational selectionof routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets . Drug Product Development for the Back of the Eye is authored by renowned oculardrug delivery experts, representing academic, clinical, and industrial org Written by top investigators in respective areas. Addresses methods of tissue isolation and drug analysis, noninvasive approaches and nanotechnology based products. Presents approaches to assess and model pharmacokinetics of the eye noninvasively as well as a comprehensive coverage of transscleral drug delivery. INDICE: Selection of Drug Delivery Approaches for the Back of the Eye: Opportunities and Unmet Needs. Microdialysis for Vitreal Pharmacokinetics. Fluorophotometry for Pharmacokinetic Assessment. Systemic Route for Retinal Drug Delivery: Role of the Blood-Retinal Barrier. Topical Drug Delivery to the Back ofthe Eye. Principles of Retinal Drug Delivery from Within the Vitreous. Transscleral Drug Delivery. Suprachoroidal and Intrascleral Drug Delivery. Advances in Biodegradable Ocular Drug Delivery Systems. Microparticles as Drug DeliverySystems for the Back of the Eye. Nanotechnology and Nanoparticles. Hydrogels for Ocular Posterior Segment Drug Delivery. Refillable Devices for Therapy of Ophthalmic Diseases. Targeted Drug Delivery to the Eye Enabled by Microneedles. Ocular Iontophoresis. Drug and Gene Therapy Mediated by Physical Methods. Protein Drug Delivery and Formulation Development. Drug Suspension Development for the Back of the Eye. Regulatory Considerations in Product Development for Back of the Eye. Clinical Endpoints for Back of the Eye Diseases. Druggable Targets and Therapeutic Agents for Disorders of the Back of the Eye. Development of Bile Acids as Anti-Apoptotic and Neuroprotective Agents in Treatment of Ocular Disease.

• ISBN: 978-1-4419-9919-1
• Editorial: Springer US
• Encuadernacion: Cartoné
• Páginas: 522
• Fecha Publicación: 29/07/2011
• Nº Volúmenes: 1
• Idioma: Inglés