Asymmetric Synthesis in Organophosphorus Chemistry: Synthetic Methods, Catalysis and Applications

Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications. As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal–, organo– and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds. Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous–containing drugs. INDICE: INTRODUCTION. FUNDAMENTALS OF STEREOCHEMISTRY OF ORGANOPHOSPHORUS COMPOUNDS . Determining Enantiomer Composition. Determining Absolute Configuration. Asymmetric Induction and Stereochemistry. . ASYMMETRIC SYNTHESIS OF P–CHIROGENIC PHOSPHOROUS COMPOUNDS . Introduction. Low–Coordinated Organophosphorus Compounds. Compounds of Tervalent Three–Coordinated Phosphorus. Asymmetric Induction at P (IV) . Enzymatic Synthesis of P–Chiral Phosphorus Compounds. Asymmetric Synthesis of P–Chirogenic P(V) and P(VI)–Phosphorus Compounds. . PHOSPHORUS COMPOUNDS WITH CHIRAL CENTRE IN SIDE CHAIN. Introduction. Asymmetric Reactions in Side Chain of Organophosphorus. Enantioselective Olefination. Stereoselective Addition of Phosphoric Nucleophiles to C=X Compounds. Asymmetric Reduction . Enantioselective Oxidation. Asymmetric Cycloaddition. . ASYMMETRIC METALLOCOMPLEX CATALYSIS OF PHOSPHORUS COMPOUNDS. Introduction. Asymmetric Catalytic Hydrogenation and Reduction Reactions. Asymmetric Oxidation. Electrophilic Asymmetric Catalysis . Nucleophilic Asymmetric Catalysis of Addition Reaction to Multiple Bonds. . ASYMMETRIC ORGANOCATALYSIS. Introduction. Quinine and its Derivatives. Sparteine as a Chirality Inductor . Proline, Amino Acids and their Derivatives. Various Examples. . ASYMMETRIC BIOCATALYSIS IN PHOSPHOROUS CHEMISTRY. Introduction. Enzymatic Synthesis of Organophosphorus Compounds. Microbiological Syntheses of Organophosphorus Compounds. . CONCLUSION.

• ISBN: 978-3-527-34150-4
• Editorial: Wiley VCH
• Encuadernacion: Cartoné
• Páginas: 392
• Fecha Publicación: 23/11/2016
• Nº Volúmenes: 1
• Idioma: Inglés