Human genetic diversity: functional consequences for health and disease

The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning ofa long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Contemporary genetic research is allowing the basis of both rare inherited disorders and common multifactorial diseases like asthma and diabetes to be more clearly defined. Huge investments are being made and great advances have been achieved, butthe challenges remain daunting. This book provides an authoritative overview of this topical and very rapidly advancing field of biomedical research. INDICE: 1: Lessons From Haemoglobin. 2: Finding Genes and Specific GeneticVariants Responsible for Disease. 3: Cytogenetics and Large Scale Structural Genomic Variation. 4: Submicroscopic Structural Variation in Health and Susceptibility to Disease. 5: Submicroscopic Structural Variation and Genomic Disorders. 6: Segmental Duplications and Indel Polymorphisms. 7: Tandem Repeats. 8: Mobile DNA Elements. 9: SNPs, HapMap and Common Disease. 10: Fine Scale Sequence Diversity and Signatures of Selection. 11: Genetics of Gene Expression. 12:Extreme Diversity in the Major Histocompatibility Complex. 13: Parasite Wars.14: Human Genetic Diversity and HIV: Lessons From a War Fought on Many Fronts. 15: Concluding Remarks and Future Directions. Glossary. References. Index.

• ISBN: 978-0-19-922770-9
• Editorial: Oxford University
• Encuadernacion: Rústica
• Páginas: 480
• Fecha Publicación: 01/09/2009
• Nº Volúmenes: 1
• Idioma: Inglés