Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles - such as mucosal and transdermal - and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery Describes the various polymer types used in the synthesis and characterization of polymeric micelles Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more INDICE: Part 1. Synthesis and characterization of polymeric micelles for drug delivery1. Polymeric micelles: History, basic concept, recent state-of-art and prospective challenges2. Various polymers in the development of polymeric micelles3. Solubility enhancement and drug release mechanism by polymeric micelles4. Surface-engineering of polymeric micelles for imparting multifunctionality5. Biofate and cellular interactions of polymeric micelles6. Pharmacokinetics and in-vitro, in-vivo evaluation of polymeric micellesPart 2. Application of polymeric micelles in drug delivery7. Polymeric micelles for oral drug delivery8. Polymeric micelles for ocular drug delivery9. Polymeric Micelles in dermal and transdermal drug delivery10. Polymeric micelles in mucosal drug delivery11. Polymeric micelles for drug delivery in oncologyPart 3. Stimuli-responsive polymeric micelles for drug delivery12. pH- responsive polymeric micelles for drug delivery13. Redox-responsive polymeric micelles for drug delivery14. Enzyme-responsive polymeric micelles for drug delivery15. Light- and temperature- responsive polymeric micelles for drug delivery16. Exogenous stimuli-responsive polymeric micelles for drug delivery17. Dual-responsive polymeric micelles for drug deliveryPart 4. Recent advances in polymeric micelles18. Polymeric micelles for drug co-delivery19. Polymeric micelles for drug delivery of genetic materials20. Polymeric micelles with cleavable links for drug delivery21. Block copolymer micelles as long-circulating drug vehicles22. Triblock polymeric micelles for drug deliveryPart 5. Environmental and regulatory aspects23. Biological toxicity and environmental hazards associated with polymeric micelles24. Clinical translation of polymeric micelles into market25. Regulatory pathways and federal perspectives on polymeric micelles
- ISBN: 978-0-323-89868-3
- Editorial: Woodhead Publishing
- Encuadernacion: Rústica
- Páginas: 510
- Fecha Publicación: 01/08/2022
- Nº Volúmenes: 1
- Idioma: Inglés