By integrating technology, supporting infrastructure and efficient application, this all–in–one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood– and non–blood–based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA– and RNA–based molecular diagnostics. INDICE: Next–Generation Sequencing for clinical diagnostics of Cardiomyopathies MicroRNAs as novel biomarkers in cardiovascular medicine MicroRNAs in primary brain tumors: functional impact and potential use for diagnostic purposes Genetic and epigenetic alterations in sporadic colorectal cancer. Clinical implications Nucleic acid based markers in urologic malignancies From the genetic make–up to the molecular signature of non–coding RNA in breast cancer Nucleic acid–based diagnostics in gynecological malignancies Nucleic Acids as Molecular Diagnostics Hematopoietic malignancies ? implications in diagnosis, prognosis and therapeutic management Techniques of nucleic acid–based diagnosis in the management of bacterial and viral infectious diseases MicroRNAs in human microbial infections and disease outcomes Towards the identification of condition–specific microbial populations from human metagenomic data Genome, Exome and Gene Panel Sequencing in a Clinical Setting Analysis of nucleic acids in single cells Detecting Dysregulated Processes and Pathways Companion diagnostics and beyond – an essential element in the puzzle of transforming healthcare Ethical, legal and psychosocial aspects of molecular genetic diagnosis
- ISBN: 978-3-527-33556-5
- Editorial: Wiley VCH
- Encuadernacion: Cartoné
- Páginas: 356
- Fecha Publicación: 12/11/2014
- Nº Volúmenes: 1
- Idioma: Inglés