Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance

Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The content covers the foundations of antibiotic drug discovery process and focuses on bacterial enzymes as drug targets, building a bridge between microbiology, structural biology, and genomic science. This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books’ content. ??Provides strategies and approaches to drug design with an aim to overcome antibiotic resistanceIncludes the most common roadblocks on the research process and learnings from failed projectsProvides potential new drug targets identified by genome mining INDICE: Part I Primer of antibiotic discovery process1. Antibacterial drug discovery: An introduction2. Druggability of a target site3. Dual inhibition as a novel strategy for antibiotic discovery4. Conserved enzymes across the bacterial pathogens serves as great drug targets5. Validation of drug targets using molecular methodologies6. Selection of Enzymatic activity assays for validation of inhibitory potential7. Computational tools to identify potential drug targets in bacteria8. Antimicrobial drug resistance and bypassing strategiesPart II Bacterial enzyme as drug targets9. Strategic identification of novel enzymes as antibacterial drug targets10. Inhibiting the replication by targeting topoisomerases11. Aminoglycoside modifying Enzymes (AMEs)12. Role of beta lactamases in antibiotic drug discovery13. Combining efflux pump inhibitory agents for broad spectrum antibacterial activity14. Ribosomal binding antibacterial agents15. DNA dependent RNA polymerase as an attractive drug target16. Polymyxins and their role as next generation inhibitory compounds17. Arresting the peptidoglycan synthesis to kill the bacteria18. Bacterial Proteases19. Targeting lipase enzyme for drug discovery20. Bacteriophage mechanisms for identification of target enzymes21. Role of regulatory RNAs as antibacterial drug targets22. Pathogen specific antibiotic discovery23. Drug Repurposing: Tackling the antibiotic resistance with existing therapeutics

• ISBN: 978-0-443-22222-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/11/2024
• Nº Volúmenes: 1
• Idioma: Inglés