Biochemical Engineering: A Textbook for Engineers, Chemists and Biologists

Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co–author Jun–ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self–study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering. INDICE: Preface.Nomenclature..PART I: Basic Concepts and Principles..INTRODUCTION.Background and Scope.Dimensions and Units.Intensive and Extensive Properties.Equilibria and Rates.Batch vs. Continuous Operation.Material Balance.Energy Balance..ELEMENTA OF PHYSICAL TRANSFER PROCESSES.Introduction.Heat Conduction and Molecular Diffusion.Fluid Flow and Momentum Transfer.Laminar vs. Turbulent Flow.Transfer Phenomena in Turbulent Flow.Film Coefficients of Heat and Mass Transfer..CHEMICAL AND BIOCHEMICAL KINETICS.Introduction.Fundamental Reaction Kinetics..CELL KINETICS.Introduction.Cell Growth.Growth Phases in Batch Culture.Factors Affecting Rates of Cell Growth.Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF)..PART II: Unit Operations and Apparatus for Bio–Systems..HEAT TRANSFER.Introduction.Overall Coefficients U and Film Coefficients h.Mean Temperature Difference.Estimation of Film Coefficients h.Estimation of Overall Coefficients U..MASS TRANSFER.Introduction.Overall Coefficients K and Film Coefficients k of Mass Transfer.Types of Mass Transfer Equipment.Models for Mass Transfer at the Interface.Liquid Phase Mass Transfer with Chemical Reactions.Correlations for Film Coefficients of Mass Transfer.Performance of Packed Column..BIOREACTORS.Introduction.Some Fundamental Concepts.Bubbling Gas–Liquid Reactors.Mechanically Stirred Tanks.Gas Dispersion in Stirred Tanks.Bubble Columns.Airlift Reactors.Packed–Bed Reactors.Microreactors..MEMBRANE PROCESSES.Introduction.Dialysis.Ultrafiltration.Microfiltration.Reverse Osmosis.Membrane Modules..CELL–LIQUID SEPARATION AND CELL DISRUPTION.Introduction.Conventional Filtration.Microfiltration.Centrifugation.Cell Disruption..STERILIZATION.Introduction.Kinetics of Thermal Death of Cells.Batch Heat Sterilization of Culture Media.Continuous Heat Sterilization of Culture Media.Sterilizing Filtration..ADSORPTION AND CHROMATOGRAPHY.Introduction.Equilibria in Adsorption.Rates of Adsorption into Adsorbent Particles.Single– and Multi–Stage Processes for Adsorption.Adsorption in Fixed Beds.Separation by Chromatography.Biorecognition Assay..PART III: Practical Aspects in Bioengineering..FERMENTOR ENGINEERING.Introduction.Stirrer Power Requirements for Non–Newtonian Liquids.Heat Transfer in Fermentors.Gas–Liquid Mass Transfer in Fermentors.Criteria for Scaling–Up Fermentors.Modes of Fermentor Operation.Fermentors for Animal Cell Culture..INSTRUMENTATION AND CONTROL OF BIOPROCESSES.Introduction.Instrumentation of Bioprocesses.Control of Bioprocesses.Advanced Control of Bioprocesses..DOWNSTREAM OPERATIONS IN BIOPROCESSES.Introduction.Separation of Microorganisms by Filtration and Microfiltration.Separation by Chromatography.Separation in Fixed Beds.Sanitation in Downstream Processes..MEDICAL DEVICES.Introduction.Blood and Its Circulation.Oxygenation of Blood.Artificial Kidney.Bioartificial Liver..Appendix.Index.

• ISBN: 978-3-527-33804-7
• Editorial: Wiley VCH
• Encuadernacion: Rústica
• Páginas: 312
• Fecha Publicación: 14/01/2015
• Nº Volúmenes: 1
• Idioma: Inglés