Translational endocrinology of bone: reproduction, metabolism, and the central nervous system

The use of model organisms together with the power of genetics has profoundlyaffected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. First, the use of mouse genetics, guided by clinical observations has revealed, besides the classical regulation by the parathyroid hormone and sex steroid hormones, totally unanticipated ways of regulating bone mass. These include the influence of adipocytes, pancreatic b-cells, and entero-chromaffin cells of the duodenum on the central and peripheralnervous systems. A second major advance of the last decade has been to show that bone has many more functions than the one classically ascribed to it and described in other textbooks. These include but are not limited to the regulation of glucose metabolism, fertility, and phosphate homeostasis. This will be the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases asdifferent as osteoporosis, type-2 diabetes, and hypo-fertility. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, andneuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

• ISBN: 978-0-12-415784-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 324
• Fecha Publicación: 13/10/2012
• Nº Volúmenes: 1
• Idioma: Inglés