Responsible Genomic Data Sharing: Challenges and Approaches

Responsible Genomic Data Sharing: Challenges and Approaches brings together international experts in genomics research, bioinformatics and digital security who analyze common challenges in genomic data sharing, privacy preserving technologies, and best practices for large-scale genomic data sharing. Practical case studies, including the Global Alliance for Genomics and Health, the Beacon Network, and the Matchmaker Exchange, are discussed in-depth, illuminating pathways forward for new genomic data sharing efforts across research and clinical practice, industry and academia. Addresses privacy preserving technologies and how they can be applied to enable responsible genomic data sharingEmploys illustrative case studies and analyzes emerging genomic data sharing efforts, common challenges and lessons learnedFeatures chapter contributions from international experts in responsible approaches to genomic data sharing INDICE: Section I: Privacy Challenges in Genomic Data Sharing 1. Criticality of data sharing in genomic research 2. Public views of genomic data sharing 3. Ethics issues in genomic data sharing (informed consent, patient-centric view, etc) 4. models of sharing genomic data (controlled access, registered users and open access) 5. Information leaks in aggregate genomic data, inference attacks Section II: Privacy-Preserving Techniques for Responsible Genomic Data Sharing 6. Overview 7. Homomorphic encryption 8. SMC 9. DP, LLR test, etc 10. Game theory approach 11. Hardware (SGX) Section III: Practices of Responsible Genomic Data Sharing 12. Genomic data sharing within large genomic research consortium (e.g, ICGC) 13. GA4GH: Building tools and standards for responsible genomic data sharing 14. Beacon 15. Matchmaker exchange for rare disease patients 16. ExAC (exome consortium)

• ISBN: 978-0-12-816197-5
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 384
• Fecha Publicación: 01/07/2019
• Nº Volúmenes: 1
• Idioma: Inglés