Molecular theory of the living cell: concepts, molecular mechanisms, and biomedical applications

The book presents the first comprehensive molecular theory of the living cellever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realisticmolecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine. First book on the molecular theory of the living cell, utilizing the principles, laws and concepts derived from physics, chemistry, computer science, linguistics, semiotics and philosophy. The book contains a most complete catalogue of the fundamental molecular mechanisms responsible for molecular processessupporting life. The book applies the molecular principles of the living cellto solving not only basic problems encountered in contemporary molecular biology such as the definition of a gene but also practical problems. INDICE: Preface. 1. Introduction. Part I. Principles, Laws, and Concepts. 2. Physics. 3. Chemistry. 4. Biology. 5. Engineering. 6. Linguistics, Semiotics, and Philosophy. Part II. Theories, Molecular Mechanisms, and Models. 7. Molecular Mechanisms of Enzymic Catalysis. 8. The Conformon. 9. Intracellular Dissipative Structures (IDSs). 10. The Living Cell. Part III. Applications: From Molecules to Mind and Evolution. 11.Subcellular Systems. 12.Whole Cells. 13.Mechanisms of the Origin of Life. 14. Principles and Mechanisms of Biological Evolution. 15. Multicellular Systems. 16. What Is Life?. 17. Why Is the Cell So Complex?. 18. Ribonoscopy and Personalized Medicine. 19. Ribonoscopy and ‘Theragnostics’. 20. Application of the Knowledge Uncertainty Principle to Biomedical Sciences. 21. Conclusions. Appendices. Glossary. References. Index.

• ISBN: 978-1-4614-2151-1
• Editorial: Springer New York
• Encuadernacion: Cartoné
• Páginas: 800
• Fecha Publicación: 28/03/2012
• Nº Volúmenes: 1
• Idioma: Inglés