Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. INDICE: Preface1. Introduction (Knud J. Jensen).2. Computational Approaches in Peptide and Protein Design: An Overview (Garland Marshall and Gregory Nikiforovich).2.1 Introduction2.2 Basics and Tools2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4AcknowledgementsReferences3. Aspects of Peptidomimetics (VeroniqueMaes and Dirk Tourwe).3.1 Introduction3.2 Modified Peptides3.3 Pseudopeptides3.4 Secondary Structure Mimics (Excluding Turn Mimics)3.5 Examples of Peptidomimetics3.6 ConclusionReferences4. Design of Cyclic Peptides (Oliver Demmer, A. O. Frank, and Horst Kessler).4.1 Introduction4.2 Peptide Cyclization4.3 Conformation and Dynamics of Cyclic Peptides4.4 Concepts in Rational Design of Cyclic Peptides4.5 Examples of Cyclic Peptides as Drug Candidates4.6 ConclusionReferences5. Carbohydrates in Design of Peptides and Proteins(Knud J. Jensen and Jesper Brask).5.1 Introduction5.2 Configurational and conformational Properties of Carbohydrates5.3 Carbohydrates in Peptidomimetics5.4Glycopeptides5.5 Carbohydrates as Scaffolds in the Design of Non-Peptide Peptidomimetics5.6 Sugar Amino Acids5.7 Cyclodextrin-Peptide Conjugate 5.8 Carboproteins: Model Proteins on Carbohydrate Templates5.9 Conclusion Remarks6. De Novo design of proteins (Knud J. Jensen).6.1 Introduction6.2 Secondary StructureElements6.3 Assembling a Specified Tertiary Structure from Secondary Structure Elements6.4 Proteins on Templates6.5 Foldamers6.6 Biopharmaceutical Applications of Protein De Novo DesignReferences7. Design of Insulin Variants for Improved Treatment of Diabetes (Thomas Høeg-Jensen).7.1 Introduction7.2 Diabetes Management and the Need for Insulin Engineering7.3 Insulin Structure7.4 Prolonged-acting Insulin Solids7.5 Prolonged-acting Insulin Solutions7.6 Fast-acting Insulins7.7 Glucose-sensitive Insulin Preparations7.8 Alternative Insulin Delivery7.9 Insulin Mimetics7.10 Pushing the Limitations of Insulin Engineering7.11 Conclusion. References. Index.
- ISBN: 978-0-470-31961-1
- Editorial: Wiley
- Encuadernacion: Cartoné
- Páginas: 294
- Fecha Publicación: 01/01/2009
- Nº Volúmenes: 1
- Idioma: Inglés