This book fills a gap in developmental books dealing with the normal prenatalmammalian brain. Most books that approach this topic work with non-human, non-vertebrate models. Mammalian Brain Development focuses on both the pre-natal and the peri-natal events that lead to brain damage as seen in the prospectiveof medical and research professionals, as well as examining the traditional “nature versus nurture” argument in the spectrum of brain development. The major topics addressed, in detail, in the book are sexual dimorphism, epigenetic action of gonadal hormones, environmental “programming” effects, autism, developmental learning disorders, seizures, and the etiopathogenesis of epileptic syndromes in young humans. The book also covers the general aspects of postnataland pediatric neurological disorders in a unique and novel way by offering definitions of heredity, inheritance, genetic-epigentic, genomic, molecular, developmental, and innate aspects of the mammalian brain in regards to its development. INDICE: Sexual differentiation of the brain: genetic, hormonal, and trophic factors.- Life at the interface between a dynamic environment and a fixed genome: Epigenetic programming of stress responses by maternal behavior.- Effects of early life seizures and anti-epileptic drug treatment on brain development in human models.- Prenatal development of the human blood-brain barrier.- Seizure propensity and brain development: a lesson from animal models.- Seizuresand antiepileptic drugs: does exposure alter normal brain development in animals models?- Overview of neural mechanisms of developmental disorders.- Drug permeation across the fetal maternal barriers.- In vivo imaging of brain development: Technologies, models, applications, and impact on understanding the etiology of mental retardation.- Congenital, non-inheritable chromosomal abnormalities responsible for neurological disorders.
- ISBN: 978-1-60761-286-5
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 350
- Fecha Publicación: 01/10/2009
- Nº Volúmenes: 1
- Idioma: Inglés