Post-transcriptional Gene Regulation in Human Disease

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats Features a summary and conclusion at the end of each chapter INDICE: 1. Regulation of Gene Expression in Mammals: An Overview2. Post Transcriptional Gene Regulation: An Overview3. Methods to Study Post-Transcriptional Regulation of Gene Expression4. Epigenetic Regulation of Post-Transcriptional Machinery5. Post-Transcriptional Regulation: A Less Explored Territory in the World of Neurodegenerative Diseases6. Role of Post-Transcriptional Gene Regulation in Hematological Malignancies7. Post-Transcriptional Gene Regulation in Solid Tumors8. A Comprehensive View of the Prostate Cancer Metastasis and Role of Androgen Receptor Splice Variants9. Post-Transcriptional Gene Regulation in Cardiorenal Syndrome10. Noncoding RNAs as Modulators of Post-Transcriptional Changes and Their Role in CVDs11. microRNAs as Critical Regulators in Heart Development and Diseases12. MicroRNA Regulation in Autoimmune Diseases13. Post-Transcriptional Regulation of Inflammatory Disorder14. Post-Transcriptional Gene Regulation in Metabolic Syndrome15. Post-Transcriptional Regulation of HIV-1 Gene Expression: Role of Viral and Host Factors16. Post-Transcriptional Regulation of Gene Expression in Entamoeba histolytica 17. Post-Transcriptional Regulation of Gene Expression in the Human Malaria Parasite Plasmodium falciparum18. Hepcidin-Induced Degradation of Iron Exporter Ferroportin Determines Anemia of Chronic Diseases19. Post-Transcriptional Regulation of Genes and Mitochondrial Disorder

• ISBN: 978-0-323-91305-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 408
• Fecha Publicación: 01/08/2022
• Nº Volúmenes: 1
• Idioma: Inglés