The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, sub-cellular organelles, and live cells are discussed. New to this second edition are recent developments in two important applications, i.e., high-resolution mechanical biosensors and the use of cell mechanics for medical diagnosis. Fully revised and expanded new edition based on the latest research and developments in the fieldExplains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work Presents recent developments of force-based biosensorsIncludes novel applications of nano-biomechanics to the medical field INDICE: 1. Force in biology2. Introduction to basic mechanics3. Force measurement and mechanical imaging apparatuses4. Interaction forces5. Polymer chain mechanics6. Analysis of data gleaned by atomic-force microscopy7. Single-molecular interaction8. Single-molecule DNA and RNA mechanics9. Single-molecule protein mechanics10. Nano-mechanics of motion supporting molecular systems11. Finite-element analysis of microbiological structures12. Cell mechanics13. Nano-rheology of living cells14. Manipulation at the molecular level
- ISBN: 978-0-444-63686-7
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 412
- Fecha Publicación: 01/12/2016
- Nº Volúmenes: 1
- Idioma: Inglés