Oxidative stress and aging: from chemistry to human dietary supplements

Oxidative stress and aging is a multi-dimensional/factorial subject matter encompassing different degrees of organism complexity (from single-cell animals to humans), different molecules (DNA, RNAs, proteins and lipids), different cellular components (mitochondria, cytoplasm and plasma membrane), different tissues and organs, and different human subpopulations including those with different 'lifestyles.' This book roughly follows this complexity hierarchy, from molecules to organisms; and within each section, pro- and anti-oxidant components will be presented and human implications will be discussed. Some overlap incoverage of topics is anticipated and this is deemed both necessary and preferable for the existing literature is often controversial. The book concludes with a chapter focusing on possible lifespan extension strategies based on our understanding of oxidative stress protection. A short preface in each of the major sections will be included to summarize the section and briefly mention other topics not specifically covered by the chapters within. The following chapter titles are tentative and will be adjusted according the contributors’ preferences. INDICE: Oxidation, Aging and lifespan: an overview and a brief assessment of the oxidative damage theory of aging.- Experimental measurements and statistical analysis of aging and lifespan.- Oxidative chemistry and markers of damaged molecules.- DNA damage.- Regulatory RNAs as a modulator of aging and lifespan.- Amino-acid/protein oxidation and aging I.- Selenoprotein and aging.- Oxidation of lipids in aging.- AGE in aging.- Oxidative damage to mitochondria and aging.- Oxidative stress and cellular energy failure.- P66shc regulation in aging and lifespan.- Brain: oxidative stress and aging brain.- Cardiovascular system.- Musculoskeletal system and aging.- Caloric restriction and oxidative stress I.- Caloric restriction and oxidative stress II.- Physical activity, oxidative stress and aging I.- Physical activity, oxidative stress and aging II.- Nutritional supplements and oxidative stress and aging.- Garlic, oxidative stress and aging.- Resveratrol and other plant polyphenols.- Cognitive decline with aging and oxidative stress.- Healthy aging strategies.

• ISBN: 978-1-60327-548-4
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 01/03/2012
• Nº Volúmenes: 1
• Idioma: Inglés