Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress. INDICE: Wnt signal production, secretion and diffusion Madelon M. Maurice and Hendrik C. Korswagen Wnt signaling at the membrane Gary Davidsonand Christof Niehrs Wnt signal transduction in the cytoplasm: an introduction to the destruction complex Tony W. Chen, Heather A. Wallace, Yashi Ahmed and Ethan Lee An overview of gene regulation by Wnt/b–catenin signaling Chen U. Zhang and Ken M. Cadigan Finding a Needle in a Genomic Haystack: Genome–wide Approaches to Identify Wnt/TCF Transcriptional Targets Chandan Bhambhani and Ken M. Cadigan Introduction to b–catenin independent Wnt signaling pathways Susanne Kühl and Michael Kühl Molecular mechanisms of Wnt pathway specificity Alexandra Schambony, Guido J.R. Zaman, Folkert Verkaar Modulation of Wnt signaling by endocytosis of receptor complexes Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, Akira Sato New insights from proteomic analysis of WNT signaling Matthew P. Walker, Dennis Goldfarband Michael B. Major New insights about Wnt pathway mechanisms from global siRNA screens Tenzin Gocha and Ramanuj DasGupta Mathematical models of Wnt signaling pathways Michael Kühl, Barbara Kracher, Alexander Groß, and Hans Kestler The Wnt’s tale: On the evolution of a signaling pathway Jenifer C. Croce and Thomas W. Holstein Secreted Wnt inhibitors or modulators Paola Bovolenta, Anne–Kathrin Gorny, Pilar Esteve and Herbert Steinbeisser Frizzleds as G protein–coupled receptors Gunnar Schulte Dishevelled, at the crossroads of pathways Vít?zslav Bryja and Ond?ej Bernatík β–catenin: a key player in both cell adhesion and wnt signaling Jonathan Pettitt Evolutionary Diversification of vertebrate TCF/LEF structure, function, and regulation Stefan Hoppler and Marian L. Waterman Insights from Structural Analysis of Protein–protein Interactions by Wnt Pathway Components and Functional Multi–protein Complex Formation Zhihong Cheng and Wenqing Xu Wnt signaling in early vertebrate development: from fertilization to gastrulation Eliza Zylkiewicz, Sergei Y. Sokol and Stefan Hoppler Wnt/ß–catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development Kathryn C. Davidson Wnt Signaling Specifying Neural Lineages Richard Dorsky Wnt signaling in Heart Organogenesis Stefan Hoppler, Silvia Mazzotta and Michael Kühl Wnt signaling in kidney organogenesis Kimmo Halt and Seppo Vainio Wnt signaling regulation of tissue architecture (EMT and MET) and morphogenesis: consequences for Colorectal and Liver Cancer T Fifis, BM Tran BM, RHM Schwab, TM Johanson, N Warner, N Barker, E Vincan Wnt signaling in adult stem cells: tissue homeostasis and regeneration Frank J.T. Staal and Riccardo Fodde Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury Günes Özhan and Gilbert Weidinger Wnt Signaling and colorectal cancer Kevin Myant and Owen J Sansom Wnt signaling in melanoma Jamie N. Anastas and Andy J. Chien Wnt Signaling in Mood & Psychotic Disorders Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya Neuropsychiatric Disease–associated Genetic Variation in the Wnt Pathway Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya Wnt Signaling in Dementia Stephen J. Haggarty Therapeutic targeting of the Wnt signaling network Felicity Rudge and Trevor Dale
- ISBN: 978-1-118-44416-0
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 504
- Fecha Publicación: 21/04/2014
- Nº Volúmenes: 1
- Idioma: Inglés