Vitamin D: physiology, molecular biology, and clinical applications

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaininggood bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence ofevents that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. Thefirst edition of Vitamin D: Physiology, Molecular Biology and Clinical Applications was the benchmark in the field when published in 1999. This new and expanded volume continues to include extensive, in-depth chapters covering the most important aspects of the complex interactions between vitamin D and other dietary components, the ongoing debate concerning the best indicator of optimalvitamin D status and its nutrient requirements, and the impact of less than optimal status on disease risk. Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiencypandemic and its clinical implications for health and disease." Most recent recommendations for vitamin D intake Comprehensive, highly readable overview ofthe biological functions and clinical applications of vitamin D and its metabolites Provides a roadmap for how to evaluate and treat patients with vitamin D deficiency INDICE: Dedication to Louis V. Avioli.- Vitamin D and Health: Evolution, Biologic Functions, and Dietary Requirements for Vitamin D.- Photobiology of Vitamin D.- The Functional Metabolism and Molecular Biology of Vitamin D.- Metabolism and Catabolism of Vitam D, its Metabolites and Clinically Relevant Analogs.- The Molecular Biology of the Vitamin D Receptor.- VDR and RXR SubcellularTrafficking.- Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport.- Biologic and Molecular Effectsof Vitamin D on Bone.- Biologic and Molecular Effect of Vitamin D on the Kidney.- Vitamin D and the Parathyroids.- Diversity of Vitamin D Target Genes.- Extra Renal Synthesis of 1,25-Dihydroxyvitamin D and Health Implications.- Vitamin D and the Innate Immunity.- Vitamin D and Colon Cancer.- Mechanisms of Resistance to Vitamin D action in Human Cancer Cells.- Vitamin D and the Brain: A Neuropsychiatric Perspective.- Vitamin D Modulation of Adipocyte Function.- Determinants of Vitamin D Intake and Vitamin D Deficiency in the United States.-25-hydroxyvitamin D Assays and Their Clinical Utility.- Health Disparity and Vitamin D Deficiency in the United States.- Vitamin D Deficiency and its Health Consequences in Canada.- Vitamin D Deficiency and its Health Consequences inNorthern Europe.- Vitamin D Deficiency and its Health Consequences in Mediterranean Countries.- Vitamin D Deficiency in the Middle East and its Health Consequences for Children.- Vitamin D Deficiency in the Middle East and its HealthConsequences for Adults.- Vitamin D Deficiency and its Health Consequences inAfrica.- Vitamin D Deficiency and its Health Consequences in India.- Vitamin D Deficiency, Rickets and Flourosis in India.- Vitamin D Deficiency and its Health Consequences in Asia.- Vitamin D Deficiency and its Health Consequences in New Zealand.- Toxicity of Vitamin D.- Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences.- Vitamin D Deficiency in Children and its Health Consequences.- Dietary Calcium Deficiency and Rickets.- Vitamin D in Fracture Prevention and Muscle Function and Fall Prevention.- Inherited Defects of Vitamin D Metabolism.- Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihyroxyvitamin D Resistant Rickets (HVDRR).- Receptor-Independent Vitamin-D Resistance in Subhuman and Human Primates.- 25-Hyroxyvitamin D-1a-hydroxylase: Studies in Mouse Models and Implications for Human Disease.- The Health Benefits of Solar Irradiance and the Consequences of its Deprivation.- Vitamin D Status, Solar Radiation and Cancer Prognosis.- Epidemiology of Vitamin D and Cancer.- Vitamin D Deficiency and the Epidemiology of Prostate Cancer.- Vitamin D for Cancer Prevention and Survival.- The Anti-Cancer Effect of Vitamin D: What do the Randomized Trials Show?.- Sunlight, Skin Cancerand Vitamin D.- Vitamin D and Risk of Type 1 Diabetes.- Vitamin D and Multiple Sclerosis.- Vitamin D and Type II Diabetes.- Role of Vitamin D for Cardiovascular Health.- Vitamin D, Renin and Blood Pressure.- Role of Vitamin D and Vitamin D Analogues for Bone Health and Survival in Chronic Kidney Disease.- Roleof Vitamin D and Ultraviolet Radiation in Chronic Kidney Disease.- Role of Vitamin D in Rheumatoid Arthritis.- Vitamin D, Respiratory Infections and Obstructive Airway Diseases.- Treatment of Immuno-mediated Diseases by Vitamin D Analogues.- Clinical Utility of 1, 25-Dihydroxyvitamin D3 and its Analogues for the Treatment of Psoriasis.- Affinity Aklylating Vitamin D Analogs as MolecularProbes and Therapeutic Agents.- Anti-inflammatory Activity of Calcitriol thatContributes to its Therapeutic and Chemopreventive Effects in Prostate Cancer.

• ISBN: 978-1-60327-300-8
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 1038
• Fecha Publicación: 01/06/2010
• Nº Volúmenes: 1
• Idioma: Inglés