Dedicated to the great chemistry pioneer Leslie Orgel, on the occasion of his80th birthday, this compilation of reviews and original manuscripts reviews the state of the art, and is written by some of the major players in this creative domain of 'explorative chemistry' (such as Christian De Duve, Albert Eschenmoser, Günter Wächtershäuser). The contributions cover theories including chemistry and selection, evolution of the pioneer organism, chemical aspects of synthetic biology, ribozyme catalysis of metabolism in the RNA world, intractable mixtures and the origin of life, the chemical etiology of nucleic acids, interstellar amino acids, and even the chemistry that preceded life's origin. The majority of the articles reproduced in this volume originally appeared in a special issue of Chemistry & Biodiversity under the same title. INDICE: 1. On Chemistry Leading to Life's Origin (P. Herdewijn, M.V. Kisakürek) 2. Reactions of the HCN-Tetramer with Aldehydes (K. Koch, W. B. Schweizer, A. Eschenmoser) 3. On a Hypothetical Generational Relationship between HCN and Constituents of the Reductive Citric Acid Cycle (A. Eschenmoser) 4. Chemistry and Selection (C. de Duve) 5. On the Chemistry and Evolution of the Pioneer Organism (G. Wächtershäuser) 6. Chemical Aspects of Synthetic Biology (P. L.Luisi) 7. Errors and Alternatives in Prebiotic Replication and Catalysis (J. Ninio) 8. Ribozyme Catalysis of Metabolism in the RNA World (X. Chen, N. Li, A. D. Ellington) 9. Intractable Mixtures and the Origin of Life (A. W. Schwartz) 10. From Interstellar Amino Acids to Prebiotic Catalytic Peptides: A Review (A. Brack) 11. The Chemistry That Preceded Life's Origin: A Study Guide from Meteorites (S. Pizzarello) 12. Formamide Chemistry and the Origin of Informational Polymers (R. Saladino, C. Crestini, F. Ciciriello, G. Costanzo, E. Di Mauro) 13. RNA: Prebiotic Product, or Biotic Invention? (C. Anastasi, F. F. Buchet, M. A. Crowe, A. L. Parkes, M. W. Powner, J. M. Smith, (J. D. Sutherland) 14.Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs) (D. Zhou, M. Froeyen, J. Rozenski, A. Van Aerschot, P. Herdewijn) 15. Nonenzymatic Recombination of RNA: Possible Mechanism for the Formation of Novel (Sequences (A. V. Lutay, M. A. Zenkova, V. V. Vlassov) 16. Addressing the Problems of BasePairing and Strand Cyclization in Template-Directed (Synthesis A Case for theUtility and Necessity of 'Molecular Midwives a'nd Reversible Backbone (Linkages for the Origin of proto-RNA (N. V. Hud, S. S. Jain, X. Li, D. G. Lynn) 17. Chemical Primer Extension: Individual Steps of Spontaneous Replication (J. A. R. Stütz, E. Kervio, C. Deck, C. Richert) 18. Conformational and Chiral Selection of Oligonucleotides (M. Froeyen, F. Morvan, J.-J. Vasseur, P. Nielsen, A. Van Aerschot, H. Rosemeyer, (P. Herdewijn 19. Preparation of Guanine and Diaminopurine from Biuret (Part III (I. M. Lagoja, P. Herdewijn) 20. RNAs in Extreme Environments (M.-C. Maurel) 21. Evolution of Optimal Accuracy and Stability in Biological Systems (R. Holliday) 22. Differences in Substrate Specificity of C(5)-Substituted or Unsubstituted Pyrimidine Nucleotides by DNA Polymerases from Thermophilic Bacteria, Archae, and Phage (H. Sawai)
- ISBN: 978-3-906390-50-5
- Editorial: Verlag Chemie
- Encuadernacion: Cartoné
- Páginas: 308
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés