Modified nucleosides: in biochemistry, biotechnology and medicine
Herdewijn, Piet
This one-stop reference for every scientist working in the field covers more than 25 compound classes. The only comprehensive overview on the field addresses biochemical aspects and applications as well as compounds with therapeutic potential. INDICE: PART I: BIOCHEMISTRY AND MOLECULAR BIOLOGY 5'-Substituted pyrimidines 7'-Substituted purines Universal bases 2'- and 4'-Thiouridine 6'-Thiopurines Locked nucleosides 2'-Fluoro-nucleosides Deazapurines Hydroxyurines and DNAdamage Modified bases and polymerases tRNA synthetase inhibitors Thymidine dimers and DNA damage ADP ribosylation inhibitors Siderophores PART II: MEDICINAL CHEMISTRY Purine receptor ligands S-Adenosy-homocysteine hydrolase modulators Formycin and other PNP inhibitors 4'-thionucleosides in cancer chemotherapy C3'-ethyl-nucleosides Neplanocin and analogues Clitocine Diazepinone riboside Adenosine kinase inhibitors Liposidomycin Sulfated nucleosides Adenophostin A S-Allyl-thioadenine PART III: ANTITUMORAL NUCLEOSIDES Azacitidine CapecitabineGemcitabine Clofarabine Nelarabine
- ISBN: 978-3-527-31820-9
- Editorial: Verlag Chemie
- Encuadernacion: Cartoné
- Páginas: 560
- Fecha Publicación: 20/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés