Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicineGathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the fieldContains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more INDICE: 1. From Mendelian Genetics to 4D-Genomics2. Genes and Genomes Represent Different Biological Entities 3. Genome Chaos and Macro-cellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer4. Chromosomal Coding and Fuzzy Inheritance5. Why sex? Genome Re-interpretation Dethrones the Queen6. Breaking the Genome Constraint: The Mechanism of Macro-evolution7. The Genome Theory: A New Framework8. The Rationale and Challenges for Precision Medicine

• ISBN: 978-0-12-813635-5
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/11/2018
• Nº Volúmenes: 1
• Idioma: Inglés