Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to both cellular processes while helping researchers to explore their potentially important connections. Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal and antibacterial immunity, and transplantation. This volume also explains in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of omegasomes to autophagosomes. This information is important because one of the major functions of autophagy is to degrade and eliminate excessive, old, and harmful materials from the cell. Autophagosomes receive these materials (cellular cargo) and transport them to lysosomes for degradation. Lysosomes contain the digestive enzymes (hydrolases) that breakdown proteins, lipids, carbohydrates, etc. (self-digestion). To further explain this phenomenon, the role of endoplasmic reticulum (ER) in the formation of autophagosomes is discussed. ULK1 and Beclin 1 proteins are also important in the initial formation of autophagosomes, which are discussed. Because much of the early research in this area was carried out using yeast cells, the role of Golgi complex in the autophagosome formation in these cells is explained. Volume 9 also includes an explanation of the role of autophagy-related gene ATG5 in cancer (e.g., gastrointestinal cancer). Paradoxically, autophagy is a double-edged sword,? because it eliminates some pathogens, whereas it can be used by some intracellular pathogens to multiply and cause infection. This book is an asset to newcomers as a concise overview of the role of autophagy in necrosis and inflammation, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases.  Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle.  Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Human Diseases and Autophagosome. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or bothIntroduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammationStates recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalitiesEdited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available INDICE: 1. Molecular Mechanisms of Selective Autophagy2. Atg9 is required for the initiation and Progression of Autophagy: Role of Autophagosome Precursor3. UVRAG at the Crossroad of Autophagy and Genomic Stability4. The End or Beginning of Autophagic Cell Death5. Atg18 is located in Omegasome-Anchored Phagophores and Regulates LC3 lipidation6. Atg2 proteins are Essential for Autophagosome Formation and Regulation of Lipid Droplets7. Progression of Omegasomes to Autophagosomes: Molecular Mechanism8. Role of ULK1 and Beclin 1-PI3KC3 in the Autophagosome Formation9. Role of Endoplasmic Reticulum in the Formation of Autophagosome10. Role of Golgi complex in the yeast Autophagosome Formation11. Recognition of Phosphatidylinositol 3-phosphate by PROPPINs12. Maintenance of Oxidative Metabolism and Tumorigenesis: Role of RAS-Activated Autophagy13. Persistent Mitochondrial DNA damage is removed by autophagy14. Autophagy Promotes T-Cell Survival through Degradation of Proteins of the Cell Death Machinery15. Cellular/ Immune Response to Stresses: Role of Autophagy16. Autophagy Attenuates the Adoptive Immune Response by Destabilizing the Immunologic Synapse17. T-Cell Survival and Proliferation: Role of Autophagy gene ATG518. Recessive Mutations in EPG5 cause Vici Syndrome: Role of Defective Autophagy19. Gastrointestinal Cancer: Role of the Autophagy-Related ATG5 Gene20. Suppression of Basal Autophagy in Neural Cells causes Neurodegenerative Disease21. Loss of Autophagy in the Central Nervous System Causes Neurodegeneration

• ISBN: 978-0-12-802936-7
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 430
• Fecha Publicación: 10/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés