Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease INDICE: L. General Applications 1. Introduction M. A. Hayat 2. Molecular Process and Physiological Significance of Mitophagy;  Ke Wang and Daniel J. Klionsky 3. Principles of Mitophagy and Beyond; Aviva M. Tolkovsky and Kim Tieu 4. Quality Control in Mitochondria; Kobi J. Simpson-Lavy and Hagai Abeliovich 5. Mitophagy: An Overview; Dalibor Mijaljica, Mark Prescot, and Rodney J. Devenish ll. Molecular Mechanisms 6. Mitophagy Induction and Curcumin-Mediated Sonodynamic Chemotherapy; Chuanshan Xu and Wingnang Leung 7. Role of Nix in the Maturation of Erythroid Cells Through Mitochondrial Autophagy; Huanhuan Sun, Lei Wang, and Min Chen 8. Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy; Jose A. Boga, Ana Coto-Montes, and Russel J. Reiter 9. Ubiquitin Ligase-Assisted Selective Autophagy of Mitochondria: Determining its Biological Significance Using Drosophila models; Tsuyoshi Inoshita and Yuzuru Imai 10. ATG32 Confers Selective Mitochondrial Sequestration as a Cargo for Autophagy; Yusuke Kurihara and Tomotake Kanki 11. PARK2 Induces Autophagy Removal of Impaired Mitochondria Via Ubiquitination; Kah-Leong Lim, Doreen S. K. Chua, Xavi Gallart Palau, and Tso-Pang Yao 12. Ubiquitination of Mitofusins in PINK1/PARKIN-Mediated Mitophagy; Mathhew E. Gegg 13. Mitochondrial Alterations and Mitophagy in Response to Hydroxydopamine; Joaquin Jordan, Maria E. Solesio, and Maria F. Galindo lll. Role in Disease 14. Role of Mitochondrial Fission and Mitophagy in Parkinson's Disease; Maria F. Galindo, Maria E. Solesio, and Joaquin Jordan 15. Mitophagy Control by the PINK1-PARKIN Pathway is Associated with Parkinson's Disease Pathogenesis;  Yuzuru Imai and Nobutaka Hattori 16. Loss of Mitochondria During Skeletal Muscle Atrophy; Sudarsanareddy Lokireddy 17. Role of Impaired Mitochondrial Autophagy in Cardiac Aging: Mechanisms and Therapeutic Implications; Emanuele Marzetti, Roberto Bernabei, Maria Lorenzi, Christiaan Leeuwenburgh, and Riccardo Calvan

• ISBN: 978-0-12-405528-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 304
• Fecha Publicación: 11/08/2014
• Nº Volúmenes: 1
• Idioma: Inglés