Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing fieldBuilds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems levelOrganized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosisExplores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast INDICE: 1: INTRODUCTION2: AUTOPHAGIC FLUX, FUSION DYNAMICS AND CELL DEATH 3: ARCHITECTURE OF THE ATG12-ATG5-ATG16 COMPLEX AND ITS MOLECULAR ROLE IN AUTOPHAGY 4: THE MOLECULAR MECHANISMS UNDERLYING AUTOPHAGOSOME FORMATION IN YEAST5: ROLE OF AUTOPHAGY IN CELL SURVIVAL IN LIVER INJURY6: POLYMORPHISMS IN AUTOPHAGY-RELATED GENES IN CROHN'S DISEASE: IMPACT ON INTRACELLULAR BACTERIA PERSISTENCE AND INFLAMMATORY RESPONSE7: FUNCTIONAL RELEVANCE OF AUTOPHAGINS IN LIFE AND DISEASE8: STRATEGIES TO BLOCK AUTOPHAGY IN TUMOUR CELLS9: AUTOPHAGIC DYSFUNCTION IN GAUCHER DISEASE AND ITS RESCUE BY CATHEPSIN B AND D PROTEASES10: CARGO RECOGNITION FAILURE UNDERLIES MACROAUTOPHAGY DEFECTS IN HUNTINGTON'S DISEASE11: HEPATITIS C VIRUS INFECTION, AUTOPHAGY AND INNATE IMMUNE RESPONSE  12: GERANYLGERANOIC ACID INDUCES INCOMPLETE AUTOPHAGY BUT LEADS TO THE ACCUMULATION OF AUTOPHAGOSOMES IN HUMAN HEPATOMA CELLS13: DEFENSE AGAINST PROTEOTOXIC STRESS IN THE HEART: ROLE OF P62, AUTOPHAGY, AND UBIQUITIN-PROTEASOME SYSTEM14: ELIMINATION OF INTRACELLULAR BACTERIA BY AUTOPHAGY15: PROTEIN PHOSPHATASE 2A HAS POSITIVE AND NEGATIVE ROLES IN AUTOPHAGY16: ERUFOSINE INDUCES AUTOPHAGY AND APOPTOSIS IN ORAL SQUAMOUS CELL CARCINOMA: ROLE OF THE AKT-MTOR SIGNALING17: EMERGING ROLE OF HYPOXIA-INDUCED AUTOPHAGY IN CANCER IMMUNOTHERAPY18: INVOLVEMENT OF AUTOPHAGY AND APOPTOSIS IN STUDIES OF ANTICANCER DRUGS19: AUTOPHAGY-BASED PROTEIN BIOMARKERS FOR IN VIVO DETECTION OF CARDIOTOXICITY IN THE CONTEXT OF CANCER THERAPY20: INHIBITION OF MTOR PATHWAY AND INDUCTION OF AUTOPHAGY BLOCK LYMPHOMA CELL GROWTH: ROLE OF AMPK ACTIVATION 21: AUTOPHAGY REGULATES OSTEOARTHRITIS-LIKE GENE EXPRESSION CHANGES: ROLE OF APOPTOSIS AND REACTIVE OXYGEN SPECIES22: THE KEY ROLE OF AUTOPHAGY AND ITS RELATIONSHIP WITH APOPTOSIS IN LEPIDOPTERAN LARVAL MIDGUT REMODELING23: INTERFERON REGULATORY FACTOR 1 REGULATES BOTH AUTOPHAGY AND APOPTOSIS IN SPLENOCYTES DURING SEPSIS24: THE INTERPLAY BETWEEN AUTOPHAGY AND APOPTOSIS

• ISBN: 978-0-12-405529-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 12/04/2014
• Nº Volúmenes: 1
• Idioma: Inglés