Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or bothIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammationCovers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities INDICE: 1: INTRODUCTION2: SELECTIVE AUTOPHAGY: ROLE OF INTERACTION BETWEEN THE ATG8-FAMILY INTERACTING MOTIF AND ATG8-FAMILY PROTEINS3: MAMNALIAN AUTOPHAGY CAN OCCUR THROUGH AN Atg5/Atg7-INDEPENDENT PATHWAY4: SELECTIVE AUTOPHAGY: ROLE OF UBIQUITIN AND UBIQUITIN-LIKE PROTEINS IN TARGETING PROTEIN AGGREGATES, ORGANELLES, AND PATHOGENS5: UBIQUITIN AND P62 IN SELECTIVE AUTOPHAGY IN MAMMALIAN CELLS6: ROLE OF THE GOLGI COMPLEX AND AUTOPHAGOSOME BIOGENESIS IN UNCONVENTIONAL PROTEIN SECRETION7: INDUCTION OF AUTOPHAGY IN HIV-1-UNINFECTED CELLS: ROLE OF FUSOGENIC ACTIVITY OF GP418: NON-LIPIDATED LC3 IS ESSENTIAL FOR MOUSE HEPATITIS VIRUS INFECTION9: SUPPRESSION OF INNATE ANTIVIRAL IMMUNITY AFTER HEPATITIS C VIRUS INFECTION: ROLE OF THE UNFOLDED PROTEIN RESPONSE AND AUTOPHAGY10: MYCOBACTERIAL SURVIVAL IN ALVEOLAR MACROPHAGES AS A RESULT OF CORONIN-1A INHIBITION OF AUTOPHAGOSOME FORMATION11: VIRULENT MYCOBACTERIA UPREGULATE INTERLEUKIN-6 (IL-6) PRODUCTION TO COMBAT INNATE IMMUNITY12: AUTOPHAGY IN PARASITIC PROTISTS13: CELL SURFACE PATHOGEN RECEPTOR CD46 INDUCES AUTOPHAGY14: HELICOBACTER PYLORI INFECTION AND AUTOPHAGY: A PARADIGM FOR HOST-MICROBE INTERACTIONS15: AUTOPHAGY IS REQUIRED DURING MONOCYTE-MACROPHAGE DIFFERENTIATION16: ROLE OF AUTOPHAGY GENE ATG5 IN T LYMPHOCYTE SURVIVAL AND PROLIFERATION17: SEPSIS INDUCED AUTOPHAGY IS A PROTECTIVE MECHANISM AGAINST CELL DEATH18: BLOCKAGE OF LYSOSOMAL DEGRADATION IS DETRIMENTAL TO CANCER CELLS SURVIVAL: ROLE OF AUTOPHAGY ACTIVATION19: AUTOPHAGY AS A SENSITIZATION TARGET IN CANCER THERAPY20: PATHOGENESIS OF BILE DUCT LESIONS IN PRIMARY BILIARY CIRRHOSIS:ROLE OF AUTOPHAGY FOLLOWED BY CELLULAR SENESCENCE21: AUTOPHAGY AND NADPH OXIDASE ACTIVITY TEND TO REGULATE ANGIOGENESIS IN PULMONARY ARTERY ENDOTHELIAL CELLS WITH PULMONARY HYPERTENSION22: ROLE OF AUTOPHAGY IN HEART DISEASE23: REGULATION OF AUTOPHAGY IN OBESITY-INDUCED CARDIAC DYSFUNCTION24: CYTOCHROME P4502E1, OXIDATIVE STRESS, JNK, AND AUTOPHAGY IN ACUTE ALCOHOL-INDUCED FATTY LIVER25: AUTOPHAGY-INDEPENDENT TUMOR SUPPRESSION: ROLE OF UV RADIATION RESISTANCE ASSOCIATED GENE26: CHAPERONE-MEDIATED AUTOPHAGY AND DEGRADATION OF MUTANT HUNTINGTIN PROTEIN27: THE ROLE OF ATG8 HOMOLOGUE IN LEWY BODY DISEASE

• ISBN: 978-0-12-405877-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 440
• Fecha Publicación: 23/12/2013
• Nº Volúmenes: 1
• Idioma: Inglés