Natural Products in Medicinal Chemistry

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 15 highly informative chapters. Using well–documented case studies from drug development projects over the past decade, this handbook and ready reference demonstrates the current importance and future potential of natural products as drug precursors, highlighting the lessons learned and pointing to future directions in the field. The examples are carefully chosen so as to represent a wide range of chemical structures as well as therapeutic indications and include such classical cases as taxol and the vinca alkaloids as well the latest developments in protease inhibitors, antimicrobials, antifungals, antisense nucleosides, and epothilones. INDICE: Introduction and Perspectives Platencin, Platensimycin and Analogues Epothilones and Analogues Vinca Alkaloids and Analogues Taxol and Analogues Hybrid Natural Products Macrolides and Antifungals via Biotransformation Camptothecin and Analogues Natural Product–derived Libraries Bryostatin and Bryologues From Phlorizine to Arylglycosides and Diabetes Cyclopamine and Congeners Unnatural Nucleosides and Antisense Therapy Morphine–like Compounds Aeruginosins as Thrombin Inhibitors

• ISBN: 978-3-527-33218-2
• Editorial: Wiley VCH
• Encuadernacion: Rústica
• Páginas: 618
• Fecha Publicación: 01/02/2014
• Nº Volúmenes: 1
• Idioma: Inglés