The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first ofwhich probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describingEGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. Probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers Describes EGF receptor in a tumor tissue specific context Illustrates the many ways in which EGF receptors contribute to abnormal survival and migration signaling in cancer cells and to epithelial-to-mesenchymal transition and metastasis INDICE: From the contents Section I: EGFR Signaling Networks - EGF receptor family extracellular domain structures and functions - EGF receptor heterodimerization and activation- Structure-function of EGFR kinase domain and inhibitors - Internalization and degradation of EGF receptor - Differential dependence of EGFR and ErbB2 on the molecular chaperone Hsp90 - Activation of STATs 3 and 5 through the EGFR Signaling Axis - The intersection of EGFR and Ras signaling pathways - Phosphoinositide 3-kinase enzymes as downstream targets of theEGF receptor - Convergence of EGF Receptor and Src Family Signaling Networks in Cancer - Molecular Crosstalk between E-cadherin and EGFR Signaling Network - Crosstalk between insulin-like growth factor (IGF) and epidermal growth factor (EGF) receptors - Negative regulation of signaling by the EGFR family - Nuclear ErbB receptors: Pathways and functions - Temporal dynamics of EGF receptor signaling by quantitative proteomics.
- ISBN: 978-1-58829-948-2
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 375
- Fecha Publicación: 01/10/2008
- Nº Volúmenes: 1
- Idioma: Inglés