Translational research connects science and clinical medicine from the bench to the bedside. In Sleep, Epilepsies, and Cognitive Impairment, the authors look back from the bedside to brain functioning underlying the clinical symptoms and reveal certain mechanisms explored by neuroscience in the overlapping fields of sleep and epilepsy. The authors discuss brain mechanisms behind epilepsy by applying the results of contemporary neuroimaging and signal analysis. This book helps the reader to see epilepsy from new viewpoints, emphasizing the role of epilepsy-activation by NREM sleep, in the cognitive impairment of certain major epilepsies. The authors describe the impact of activations of interictal and ictal events during NREM sleep with special emphasis to the cognitive impairment consequences. Epileptic disorders are approached by the network concept, especially in relation to the derailment of certain physiological systems transformed to epileptic networks. Sleep, Epilepsies, and Cognitive Impairment looks at epilepsy with a fresh eye, armed by contemporary neuroscience, and tries to enlighten epilepsy syndromes in new aspects. The aim is to interpret the major epileptic syndromes as system epilepsies; involving brain physiological networks. The authors endeavor to reveal the links between brain plasticity, epilepsy and NREM sleep. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought-provoking. It offers good brain-gymnastics for reconsidering the ideas on epilepsy. Provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsiesTreats major epilepsies as system epileptic networksReveals the interrelationship of sleep and epilepsy from new viewpoints INDICE: IntroductionGeneral considerationsThe network concept of epilepsyActivation of epilepsy in sleepAbsence Epilepsy as system epilepsy of the sleep promoting functionNocturnal Frontal Lobe Epilepsy as epilepsy of the arousal system from sleepJuvenile Idiopathic Myoclonic Epilepsy as the common disorder of the cortoco-thalamic and motpr systemReading Epilepsy as epilepsy of the speech functionMedial Temporal Lobe Epilepsy as epilepsy of the limbic system of declarative memory processing Peri-sylvian epileptic network: childhood idiopathic benign regional hyperexcitability (HIEC) conditions (Rolandic Epilepsy, Panayitopoulos syndrome)- Common features in HIEC conditionsMalignant transformation of HIEC conditions to Electrical status Epilepticus in Sleep in global (ESES) and regional (Landai-Kleffner Syndrome ) forms.The spectrum disorders of the peri-sylvian epileptic network Epileptic Encephalopathies (West Syndrome, Lennox-Gastaut Syndrome - Common features of Epileptic Encephalopathies.The common mechanisms in childhood epileptic encephalopathies with immense sleep activation and cortical pathological HFO activity The outstanding role of interictal dicharges (IEDs) in epileptic encephalopathies and in cognitive impairment of epilepsyThe role of slow wave sleep in the development and progression in system epilepsiesEpilepsy types in an other wayEpilogue
- ISBN: 978-0-12-812579-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 150
- Fecha Publicación: 01/11/2017
- Nº Volúmenes: 1
- Idioma: Inglés