Mitochondrial medicine: mitochondrial metabolism, diseases, diagnosis and therapy

Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics. This book is based upon extensive data gathered over 30 years of clinical and experimental research. Internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mitochondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology, and guide readers through thedisease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects. Divided into four fundamental parts: metabolism, diseases, diagnoseand therapy. Based on mitochondrial estimations during many years in clinicaland experimental medicine. Comprehensive overview on the topic. Intended for post- and pre-graduate education INDICE: List of Contributors.- Dedication.- Preface.- Acknowledgements.- List of Figures.- Mitochondrial physiology.- Oxidants, antioxidants and oxidative stress.- Chronobiology, chronomics and N-of-1 tests of timing coenzyme Q10.- Methods of chronobiometric analysis of mitochondrial function.- Mitochondrial medicine.- Mitochondrial cardiology.- Mitochondria of the human transplantedheart.- Mitochondrial diabetology.- Mitochondrial nephrology.- Mitochondria of skeletal muscle.- Rheumatoid arthritis.- Mitochondrial immunology.- Mitochondrial ‘spermatopathy’.- Methods for diagnosis of mitochondrial diseases.- Nuclear Magnetic Resonance.- Clinical aspects of coenzyme Q10 in relationship withits bioenergetic and antioxidant properties.- Coenzyme Q10 supplementation inclinical medicine.- Coenzyme Q10 supplementation in experimental medicine.- w-3-PUFA, w -6-PUFA.- Carnitine.- Vitamins in mitochondrial function.- Polarized light.

• ISBN: 978-1-4020-6713-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 409
• Fecha Publicación: 27/02/2008
• Nº Volúmenes: 1
• Idioma: Inglés