Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets

Viral polymerases constitute a vital component in the life cycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favourable targets for the design and development of antiviral drugs. The most dangerous viruses, threatening the life of human beings and containing polymerases, have been the hepatitis viruses (particularly B and C), herpesviruses, HIV, and influenza virus. Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth studies made on the structure and functions of polymerases and their roles in life cycle of viruses and as drug targets Provides comprehensive, state-of-the-art coverage of virus infections, the virus life cycle, and mechanisms of polymerase inhibition Analyses structure-activity relationships of inhibitors of each viral polymerasePresents a consistent and comprehensive coverage of all aspects of viral polymerases, such as structures, functions and their roles as antiviral drug targets INDICE: 1. Viruses Containing Polymerases and Their Life Cycles 2. General and Common Features of Viral Polymerases 3. Substrate and Ligand Binding Specificity in Polymerases 4. Design and Development of Inhibitors of Different Viral Polymerases 5. Structure-Activity Relationship Studies on Inhibitors of Individual Viral Polymerase 6. In Silico Design of Inhibitors of Viral Polymerases 7. The Success and Failure of Antiviral Therapy based on Polymerases

• ISBN: 978-0-12-815422-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/11/2018
• Nº Volúmenes: 1
• Idioma: Inglés